Pei-Yong Shi Selected Research

Dengue (Dengue Fever)

10/2020	Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses.
3/2020	Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses.
1/2020	A cocrystal structure of dengue capsid protein in complex of inhibitor.
1/2020	Vesicular Stomatitis Virus and DNA Vaccines Expressing Zika Virus Nonstructural Protein 1 Induce Substantial but Not Sterilizing Protection against Zika Virus Infection.
12/2019	Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2',5(3H)-dione Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection.
11/2019	Dengue NS2A Protein Orchestrates Virus Assembly.
1/2019	Use of the immunoglobulin G avidity assay to differentiate between recent Zika and past dengue virus infections.
1/2018	K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B.
1/2018	Discovery of Potent Non-nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from Fragment Screening and Structure-Guided Design.
12/2017	Small Molecules and Antibodies for Zika Therapy.

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Pei-Yong Shi Research Topics

Disease

76	Infections 12/2022 - 09/2003
42	COVID-19 02/2022 - 01/2020
39	Dengue (Dengue Fever) 10/2020 - 09/2003
25	Virus Diseases (Viral Diseases) 01/2022 - 02/2005
18	Zika Virus Infection 01/2021 - 12/2016
12	Viremia 11/2020 - 12/2009
11	Flavivirus Infections 02/2021 - 01/2006
8	West Nile Fever 01/2017 - 09/2003
7	Inflammation (Inflammations) 11/2022 - 10/2014
7	Yellow Fever 07/2020 - 03/2006
5	Vesicular Stomatitis 07/2021 - 02/2009
4	Glioblastoma (Glioblastoma Multiforme) 11/2021 - 10/2017
4	Body Weight (Weight, Body) 01/2020 - 08/2010
3	Weight Loss (Weight Reduction) 10/2021 - 01/2021
3	Communicable Diseases (Infectious Diseases) 07/2021 - 01/2015
3	Congenital Abnormalities (Deformity) 01/2018 - 01/2017
2	Coronavirus Infections 01/2022 - 06/2021
2	Weight Gain 01/2022 - 06/2021
2	Pneumonia (Pneumonitis) 11/2021 - 11/2020
2	Neoplasms (Cancer) 11/2021 - 01/2018
2	Severe Acute Respiratory Syndrome 01/2021 - 10/2020
2	Disease Progression 12/2020 - 10/2015
2	Encephalitis (Encephalitis, Rasmussen) 01/2020 - 10/2015
2	Guillain-Barre Syndrome 10/2019 - 12/2016
2	Japanese Encephalitis 11/2018 - 01/2018
2	Microcephaly 11/2017 - 12/2016
2	Fever (Fevers) 10/2016 - 01/2016
2	Superinfection 09/2014 - 11/2009
1	Human Influenza (Influenza) 01/2022
1	Myocarditis (Carditis) 04/2021
1	Vaccinia 01/2021
1	Laboratory Infection 01/2021

Drug/Important Bio-Agent (IBA)

57	VaccinesIBA 12/2022 - 12/2009
45	Antiviral Agents (Antivirals)IBA 01/2022 - 03/2006
38	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2003
19	RNA (Ribonucleic Acid)IBA 01/2022 - 04/2005
17	Neutralizing AntibodiesIBA 02/2022 - 02/2014
16	AntibodiesIBA 03/2021 - 07/2006
13	Viral RNAIBA 01/2022 - 04/2006
12	Pharmaceutical PreparationsIBA 01/2022 - 09/2011
9	NucleosidesIBA 01/2022 - 12/2009
7	ProdrugsIBA 01/2022 - 08/2010
7	InterferonsIBA 01/2021 - 02/2005
6	BNT162 VaccineIBA 12/2022 - 10/2020
6	CytokinesIBA 04/2021 - 07/2009
4	remdesivirIBA 01/2022 - 01/2021
4	Attenuated VaccinesIBA 02/2021 - 01/2018
4	Immunoglobulin G (IgG)IBA 01/2021 - 01/2019
4	Immunoglobulin M (IgM)IBA 01/2021 - 02/2017
4	Peptide Hydrolases (Proteases)FDA Link 11/2019 - 12/2009
4	EnzymesIBA 10/2017 - 11/2012
3	Alanine (L-Alanine)FDA Link 03/2022 - 10/2021
3	2019-nCoV Vaccine mRNA-1273IBA 10/2021 - 01/2021
3	mRNA VaccinesIBA 02/2021 - 10/2020
3	Interferon Type IIBA 12/2020 - 05/2013
3	triphosphoric acid (triphosphate)IBA 11/2020 - 02/2014
3	Peptides (Polypeptides)IBA 10/2020 - 09/2014
3	3' Untranslated Regions (3' UTR)IBA 04/2020 - 01/2017
3	PolyproteinsIBA 10/2019 - 11/2017
3	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 01/2018 - 12/2009
3	LuciferasesIBA 01/2017 - 04/2006
2	Immunoglobulin A (IgA)IBA 11/2022 - 11/2021
2	JIB-04IBA 01/2022 - 06/2021
2	aluminum sulfate (alum)IBA 11/2021 - 11/2021
2	SARS-CoV-2 spike proteinIBA 07/2021 - 02/2021
2	Glycoproteins (Glycoprotein)IBA 03/2021 - 10/2020
2	Adenosine (Adenocard)FDA LinkGeneric 01/2021 - 10/2015
2	Complementary DNA (cDNA)IBA 01/2021 - 12/2013
2	phosphoramidic acidIBA 11/2020 - 01/2018
2	DNA (Deoxyribonucleic Acid)IBA 10/2020 - 03/2020
2	Type I DNA Topoisomerases (Topoisomerase I)IBA 10/2020 - 03/2020
2	Interferon LambdaIBA 01/2020 - 07/2009
2	MethyltransferasesIBA 01/2020 - 04/2007
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2020 - 11/2018
2	Viral ProteinsIBA 01/2018 - 10/2014
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2018 - 01/2017
2	Interferon-betaIBA 01/2017 - 07/2004
2	AntigensIBA 12/2016 - 06/2015
2	NITD008IBA 10/2015 - 12/2009
2	Membrane Proteins (Integral Membrane Proteins)IBA 11/2012 - 08/2010
2	m7GpppAIBA 08/2010 - 04/2007
1	N-(2-cyanoethylene)urea (BA 1)IBA 12/2022
1	RNA Helicases (RNA Helicase)IBA 01/2022
1	GS-441524IBA 01/2022
1	Double-Stranded RNA (RNA, Double Stranded)IBA 01/2022
1	SiliconIBA 11/2021
1	Threonine (L-Threonine)FDA Link 10/2021
1	NucleotidesIBA 04/2021
1	Monoclonal AntibodiesIBA 01/2021
1	FurinIBA 01/2021
1	NucleoproteinsIBA 01/2021
1	Retinaldehyde (Retinal)IBA 01/2021
1	Angiotensin-Converting Enzyme 2IBA 01/2021
1	compound 17IBA 11/2020

Therapy/Procedure

31	Therapeutics 02/2022 - 01/2006
3	Oral Administration 11/2020 - 01/2011
2	Microspheres (Microsphere) 01/2019 - 07/2006
2	Blood Transfusion (Blood Transfusions) 11/2003 - 09/2003
2	Organ Transplantation 11/2003 - 09/2003
1	Intranasal Administration 01/2021